Barack Obama's selection of Delaware's Sen. Joe Biden to be his running mate should not have a major impact on control of the U.S. Senate.
Currently Democrats have a 51-49 seat advantage and are hoping to expand that to a filibuster proof majority of 60 seats with victories in November. While Democrats are expected to pick up some seats, getting to 60 is looking very hard.
It is unlikely, however, that Democrats will lose control of Biden's seat in the Senate if he and Barack Obama take the White House.