American Future Fund, a conservative-leaning advocacy group, is targeting U.S. Senate Majority Leader Harry Reid (D-Searchlight) for the second time in less than a month.

In a one-minute radio advertisement airing statewide in Nevada, the organization hammers Reid for his leadership on the issue of gas prices.

“How’s Harry Reid using his position as Majority Leader to help lower gas prices?” an announcer asks in the ad. “Reid and Congress just took a five week vacation -- instead of working to lower gas prices. Congress found time to pass National Apple Month, but Reid continues to block votes to explore for energy in America. America has huge energy reserves, but Congress has placed up to 85 percent of them off-limits. Reid repeatedly blocks efforts to lift the moratorium on safe exploration off our coasts. Reid opposes exploring a tiny portion of Alaska -- less land than the Las Vegas airport -- and he’s against developing our massive oil shale reserves. Call Harry Reid: 702-388-5020. Tell him his vacation should end and the Senate should vote on S. 3202.”

The ad launches today and will be airing for the next two weeks. A spokesman for American Future Fund said the total cost of the buy is $30,000. The launch comes just weeks after the organization took aim at Reid in another statewide radio spot on the issue of gas prices.

Reid's office fired back at the spot.

“It’s clear the American Future Fund is out of touch with reality – Sen. Reid is not on vacation. In fact, he’s leading a bipartisan congressional delegation to central Asia and Europe that focuses on the fight against terrorism, global climate change and the development of democracies in central Asia,” said Reid spokesman Blair Hinderliter.

Since launching its efforts earlier this year, American Future Fund has largely focused its advocacy work on competitive Senate contests. The organization has aired advertisements in Colorado and Minnesota.

Reid is not up for re-election in the current cycle but is seen as a top Republican target in 2010.